R-universe - richjjackson (Richard Jackson)

psc - Personalised Synthetic Controls

Allows the comparison of data cohorts (DC) against a Counter Factual Model (CFM) and measures the difference in terms of an efficacy parameter. Allows the application of Personalised Synthetic Controls.

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5.50 score 2 stars 1 dependents 21 scripts 306 downloads

chestR - Kernel-Weighted Cox Regression for Treatment Effect Heterogeneity

Explores treatment effect heterogeneity and candidate predictive biomarkers by re-fitting weighted Cox proportional hazards models on a biomarker grid. Kernel weights centred at each grid point produce local coefficient estimates that can be visualised across biomarker space. Builds on ideas related to graphical Cox treatment-covariate interaction methods [see Bonetti and Gelber (2004) <doi:10.1093/biostatistics/kxh002> and local partial-likelihood approaches Fan, Lin and Zhou (2006) <doi:10.1214/009053605000000796>].

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4.30 score 436 downloads

pscDesign - Study Design for Personalised Synthetic Controls

Tools for the design of prospective studies using Personalised Synthetic Controls. Can be used in either single arm or randomised studies.

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4.30 score 1 stars 3 scripts 187 downloads